TB-500
TB-500 appears in 1,177 indexed publications going back to 1982, including 33 in the past twelve months. 15 registered trials appear on ClinicalTrials.gov.
On This Figure
Most of this literature studies thymosin beta 4, the endogenous protein TB-500 is derived from, rather than the TB-500 fragment itself.
Publication history
How much work has been indexed each year, from Europe PMC. Momentum is measured over a trailing twelve months rather than calendar years, so a partial current year never reads as a decline.
Publications per year. The final bar is the current year, still in progress.
| 2015 | 45 |
|---|---|
| 2016 | 36 |
| 2017 | 38 |
| 2018 | 43 |
| 2019 | 27 |
| 2020 | 22 |
| 2021 | 42 |
| 2022 | 24 |
| 2023 | 34 |
| 2024 | 13 |
| 2025 | 26 |
| 2026 | 27 |
Who is looking it up
Monthly readers of the TB-500 article on English Wikipedia. An independent measure of curiosity, which often moves quite differently from the evidence.
The registered pipeline
Phase distribution across the most recently updated registered trials.
- Completed·Phase 3
Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3
ReGenTree, LLC · completed 2020-11-08
- Not yet recruiting·Phase 2
Recombinant Human Thymosin Beta 4 for Injection(NL005) for Acute Myocardial Infarction
Beijing Northland Biotech. Co., Ltd. · estimated completion 2027-08-17
- Recruiting·Phase 1
TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD
Hudson Biotech · estimated completion 2027-02-14
- Recruiting·Phase 3
ReGenTree, LLC · completed 2026-04-30
- Terminated·Phase 3
ReGenTree, LLC · completed 2019-11-20
- Completed·Phase 3
Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome : ARISE-2
ReGenTree, LLC · completed 2017-09
Most recent work
The newest indexed records mentioning TB-500, listed by publication date. Titles are shown as published and link to their source. Inclusion here is a record of what exists, not a judgement of what it shows.
- 2026-07-10·Experimental eye research
Banga L, Shawky M, Ebrahim F et al.
- 2026-08-24·Current pain and headache reports
Luansritisakul C, Chiang MC, Burns SL et al.
- 2026-08-17·Molecular biomedicine
Zhao TR, Hu EB, Wang MW et al.
- 2026-08-11·The American journal of sports medicine
Peptide Supplements and Their Therapeutic Applications in Sports Medicine
Tewari K, Liu TP, Im C et al.
- 2026-08-01·Clinical science (London, England : 1979)
Thymosin β4 alleviates sepsis-associated acute kidney injury by suppressing MAPK signaling pathway
Ouyang X, Long Z, Xu X et al.
- 2026-04-12·Sports medicine (Auckland, N.Z.)
Mendias CL, Awan TM. et al.
- 2026-07-23·Joint diseases and related surgery
Biçer O, Adanir O, Güleryüz Y et al.
- 2026-07-01·Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Li YX, Chen CL, Zheng SD et al.
Sources
Publication data from Europe PMC. Clinical trial data from ClinicalTrials.gov, U.S. National Library of Medicine. Public attention from Wikimedia pageview data. Evidence grades from reptides.co. We report counts and dates from these sources and link every record to its origin, we do not summarise findings. Last synced 2026-09-13.