MOTS-c

Accelerating

MOTS-c appears in 276 indexed publications going back to 2015, including 58 in the past twelve months. 4 registered trials appear on ClinicalTrials.gov.

276

Indexed publications

Past 12 months, against 45 the year before

Registered clinical trials

3,540

Monthly readers on Wikipedia, down 25%

Research Activity

Publication history

How much work has been indexed each year, from Europe PMC. Momentum is measured over a trailing twelve months rather than calendar years, so a partial current year never reads as a decline.

20152026

Publications per year. The final bar is the current year, still in progress.

Indexed publications per year
2015	4
2016	3
2017	3
2018	13
2019	22
2020	14
2021	31
2022	22
2023	35
2024	32
2025	46
2026	49

Public Attention

Who is looking it up

Monthly readers of the MOTS-c article on English Wikipedia. An independent measure of curiosity, which often moves quite differently from the evidence.

2025-092026-08

Clinical Trials

The registered pipeline

Early Phase 1

Phase 1

Phase 2

Phase 3

Phase 4

Phase distribution across the most recently updated registered trials.

Recruiting·Not applicable
Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation
University of Gaziantep · estimated completion 2026-10-01
Recruiting·Phase 2
MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity
Hudson Biotech · estimated completion 2027-02-14
Recruiting
The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination
University of Athens · estimated completion 2026-12-31
Status unknown
Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CAD
University of Athens · completed 2019-12-31

References

Most recent work

The newest indexed records mentioning MOTS-c, listed by publication date. Titles are shown as published and link to their source. Inclusion here is a record of what exists, not a judgement of what it shows.

2026-08-14·Bioactive materials
Mitochondria-derived peptide hydrogel augments mitochondrial transplantation for promoting cardiac repair via macrophage metabolic reprogramming
Li H, Zhang Y, Jian Y et al.
2026-08-23·European journal of pharmacology
MOTS-c in sepsis-induced cardiomyopathy: Mechanisms and translational potential
Zhao Z, Chen W, Zheng X et al.
2026-09-09·Scientific reports
Correction: Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction
Kutuk IS, Akin S, Demirel H et al.
2026-08-25·Physiology international
Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review
Ayubi N, Wibawa JC, Kurnaz M et al.
2026-08-18·eLife
MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide
Rice MC, Imun M, Jung SW et al.
2026-08-10·Epigenomics
Emerging regulators of human physiology and disease; sORF-encoded microproteins
Mustafa AM, Ali RM, Omar SS et al.
2026-06-25·Experimental physiology
Circulating mitochondrial-derived microproteins at rest and in response to an acute bout of endurance exercise in individuals with cerebral palsy
Horwath O, Corell L, Wan J et al.
2026-06-19·Experimental physiology
Mitochondrial peptide MOTS-c suppresses systemic and cardiac inflammasome activation in a diabetic rat model
Mills AR, de Souza A, Pham T et al.

In the Catalogue

MOTS-c available from Polaris Research

MOTS-c 10mg

Weight & Metabolism

$1.09View product

Supplied as research materials for laboratory use. Free express delivery Australia wide.

Sources

Publication data from Europe PMC. Clinical trial data from ClinicalTrials.gov, U.S. National Library of Medicine. Public attention from Wikimedia pageview data. Evidence grades from reptides.co. We report counts and dates from these sources and link every record to its origin, we do not summarise findings. Last synced 2026-09-13.