NAD+

Accelerating

NAD+ appears in 3,111 indexed publications going back to 2017, including 354 in the past twelve months. 208 registered trials appear on ClinicalTrials.gov, 2 with Australian sites.

3,111

Indexed publications

354

Past 12 months, against 276 the year before

208

Registered clinical trials

13,323

Monthly readers on Wikipedia, down 3%

On This Figure
NAD+ is a coenzyme present in every living cell, so this figure describes an entire field of metabolic research rather than one compound.

Research Activity

Publication history

How much work has been indexed each year, from Europe PMC. Momentum is measured over a trailing twelve months rather than calendar years, so a partial current year never reads as a decline.

20152026

Publications per year. The final bar is the current year, still in progress.

Indexed publications per year
2015	0
2016	0
2017	2
2018	6
2019	16
2020	27
2021	50
2022	106
2023	123
2024	193
2025	230
2026	247

Public Attention

Who is looking it up

Monthly readers of the NAD+ article on English Wikipedia. An independent measure of curiosity, which often moves quite differently from the evidence.

2025-092026-08

Clinical Trials

The registered pipeline

Early Phase 1

Phase 1

Phase 2

Phase 3

Phase 4

2 trials have a registered Australian site.

Phase distribution across the most recently updated registered trials.

Recruiting·Not applicable
ACEs, SIRT1, and Premature Vascular Aging in Humans
University of Wisconsin, Madison · estimated completion 2026-12-31
Not yet recruiting·Not applicable
A Clinical Trial to Assess the Absorption, Safety, and Efficacy of an Oral Nicotinamide Adenine Dinucleotide (NAD+) Supplement in Healthy Adults
Reus Research · estimated completion 2027-03
Not yet recruiting·Phase 3
Edaravone Dexborneol for Post-Stroke Epilepsy
First Affiliated Hospital of Wenzhou Medical University · estimated completion 2030-06
Recruiting·Not applicable
Mechanistic Study of Nicotinamide Riboside on NAD+ Biology in Individuals With Combined Pulmonary Hypertension
Vanderbilt University Medical Center · estimated completion 2027-04-30
Recruiting·Phase 1
A IB/II Phase Clinical Study on the Safety, Tolerability, and Efficacy of SHR-9839(sc) in Combination Anti-tumor Therapy in Patients With Solid Tumors
Suzhou Suncadia Biopharmaceuticals Co., Ltd. · estimated completion 2027-04
Completed·Not applicable
NAD+ and Exercise in FA
Children's Hospital of Philadelphia · completed 2025-02-07

References

Most recent work

The newest indexed records mentioning NAD+, listed by publication date. Titles are shown as published and link to their source. Inclusion here is a record of what exists, not a judgement of what it shows.

2026-06-27·Bioactive materials
A senescent metabolism-modulating hierarchical scaffold restores NAD+ homeostasis and redox balance for aged bone repair
Jiang J, Chen J, Wang X et al.
2026-02-12·Pharmaceutical science advances
NAD+ precursor supplementation reverses CD36-mediated lipid accumulation and ferroptosis to restore antitumor function of NK cells in DLBCL
Shi L, Huang X, Han X et al.
2026-04-16·Renal failure
Targeting the NAD+-SIRT3 axis to mitigate metabolic memory in diabetic kidney disease
Zhang Y, Wang Y, Qiao Y et al.
2026-03-10·Gut microbes
Bacteroides-associated NAD⁺ depletion correlates with exacerbated radiation-induced colorectal injury and impaired mucosal proliferative capacity
Huang J, Qin Q, Li X et al.
2026-08-02·Theriogenology
Nicotinamide improves bovine blastocyst quality and implantation potential by modulating matrix metalloproteinase expression
El-Sheikh M, Mesalam A, Lee SH et al.
2026-07-20·Biochemical pharmacology
Decoding lactate signals in Alzheimer's disease: redox control, receptor pharmacology, lactylation chemistry, and neuroglial vulnerability
Zaman W, Ayaz A, Ullah A. et al.
2026-06-21·Bioresource technology
Biosensor-driven adaptive laboratory evolution and modular pathway engineering for high-level production of nicotinamide mononucleotide in yeast
Shi R, Han Q, Xu Y et al.
2026-04-27·Biomaterials
Local inhibition of glaucomatous mitochondrial dysfunction using an engineered annular sector microneedle
Huang B, Xu W, Qiu X et al.

In the Catalogue

NAD+ available from Polaris Research

NAD+ 1000mg

Energy & Longevity

$1.79View product

Supplied as research materials for laboratory use. Free express delivery Australia wide.

Sources

Publication data from Europe PMC. Clinical trial data from ClinicalTrials.gov, U.S. National Library of Medicine. Public attention from Wikimedia pageview data. Evidence grades from reptides.co. We report counts and dates from these sources and link every record to its origin, we do not summarise findings. Last synced 2026-09-13.